Recombinant Mouse DDR1 Kinase/MCK10 Protein (Fc Tag) | PKSM040463

Recombinant Mouse DDR1 Kinase/MCK10 Protein (Fc Tag) | PKSM040463 | Gentaur US, UK & Europe Disrtribition

Synonyms: 6030432F18;AI323681;Cak;CD167a;Nep;PTK3A

Active Protein: N/A

Activity: A DNA sequence encoding the extracellular domain of mouse DDR1 (NP_766550.1) (Met 1-Thr 414) was fused with the Fc region of human IgG1 at the C-terminus

Protein Construction: A DNA sequence encoding the extracellular domain of mouse DDR1 (NP_766550.1) (Met 1-Thr 414) was fused with the Fc region of human IgG1 at the C-terminus

Fusion Tag: C-Fc

Species: Mouse

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 71 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.

Research Area: N/A