Description
Recombinant Mouse CD64/FCGR1 Protein (His Tag) | PKSM041015 | Gentaur US, UK & Europe Disrtribition
Synonyms: High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI; CD64;FcgammaRI;IGGHAFC
Active Protein: N/A
Activity: Recombinant Mouse High affinity immunoglobulin gamma Fc receptor I is produced by our Mammalian expression system and the target gene encoding Glu25-Pro297 is expressed with a 6His tag at the C-terminus.
Protein Construction: Recombinant Mouse High affinity immunoglobulin gamma Fc receptor I is produced by our Mammalian expression system and the target gene encoding Glu25-Pro297 is expressed with a 6His tag at the C-terminus.
Fusion Tag: C-6His
Species: Mouse
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 31.5 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: CD64, also known as Fc-gamma receptor 1 (FcγRI), is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity. After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation. CD64 is composed of a signal peptide, three extracellular immunoglobulin domains of the C2-type used to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 mediates endocytosis, phagocytosis, antibody-dependent cellular cytotoxicity, cytokine release, and superoxide production. It is normally expressed on the surfaces of monocytes and macrophages.
Research Area: N/A
