Description
Recombinant Mouse Carbonic Anhydrase 4/CA4 Protein (aa 18-277, His Tag) | PKSM040973 | Gentaur US, UK & Europe Disrtribition
Synonyms: CA4;CAIV;CA-IV;Car4;Carbonate dehydratase IV;carbonic anhydrase 4;carbonic anhydrase IVRP17;carbonic dehydratase IV;EC4.2.1.1;retinitis pigmentosa 17;RP17
Active Protein: N/A
Activity: Recombinant Mouse Carbonic anhydrase 4 is produced by our Mammalian expression system and the target gene encoding Glu18-Ser277 is expressed with a 6His tag at the C-terminus.
Protein Construction: Recombinant Mouse Carbonic anhydrase 4 is produced by our Mammalian expression system and the target gene encoding Glu18-Ser277 is expressed with a 6His tag at the C-terminus.
Fusion Tag: C-6His
Species: Mouse
Expressed Host: Human Cells
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Molecular Mass: 30.5 kDa
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH8.0.
Reconstitution: Not Applicable
Background: Carbonic anhydrase 4(CA4) is an enzyme that belongs to the alpha-carbonic anhydrase family. CA4 consists of a signal peptide (residues1-17), an ectodomain (residues18-277) and a propeptide (residues278-305), which is removed in the mature form. it is predominantly expressed in the embryo. CA4 can catalyzes the reversible reaction of CO2+H2O=HCO3-+H+, and stimulates the sodium/bicarbonate transporter activity of SLC4A4. Studies have shown that this protein have a role in inherited renal abnormalities of bicarbonate transport. Alpha-carbonic anhydrase family participate in avariety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor. They show extensive diversity in tissue is attribution and in their sub cellular localization.
Research Area: N/A
