Recombinant Human VWC2/Brorin Protein (His Tag) | PKSH030918

Recombinant Human VWC2/Brorin Protein (His Tag) | PKSH030918 | Gentaur US, UK & Europe Disrtribition

Synonyms: PSST739;UNQ739

Active Protein: N/A

Activity: A DNA sequence encoding the human VWC2 (NP_940972.2) (Met 1-Met 325) was expressed; fused with a polyhistidine tag at the C-terminus.

Protein Construction: A DNA sequence encoding the human VWC2 (NP_940972.2) (Met 1-Met 325) was expressed; fused with a polyhistidine tag at the C-terminus.

Fusion Tag: C-His

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 34.1 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Brorin; also known as brain-specific chordin-like protein; von Willebrand factor C domain-containing protein 2 and VWC2; is a secreted protein which contains two VWFC domains. VWC2 / Brorin is a BMP antagonist which may play a role in neural development. It promotes cell adhesion. VWC2 / Brorin is a unique member of the chordin family. It inhibited the activity of bone morphogenetic protein 2 (BMP2) and BMP6 in mouse preosteoblastic MC3T3-E1 cells. Mouse Brorin was predominantly expressed in neural tissues in embryos and also predominantly expressed in the adult brain. In the brain; the expression was detected in neurons; but not glial cells. The neural tissue-specific expression profile of Brorin is quite distinct from that of any other member of the Chordin family. VWC2 / Brorin protein promoted neurogenesis; but not astrogenesis; in mouse neural precursor cells. VWC2 / Brorin is a novel secreted BMP antagonist that potentially plays roles in neural development and functions.

Research Area: N/A