Description
Recombinant Human Vaspin/SerpinA12 Protein (His Tag) | PKSH033533 | Gentaur US, UK & Europe Disrtribition
Synonyms: Serpin A12; OL-64; Visceral adipose tissue-derived serine protease inhibitor; Vaspin; Visceral adipose-specific serpin; SERPINA12
Active Protein: N/A
Activity: Recombinant Human Serpin A12 is produced by our Mammalian expression system and the target gene encoding Leu21-Lys414 is expressed with a 10His tag at the C-terminus.
Protein Construction: Recombinant Human Serpin A12 is produced by our Mammalian expression system and the target gene encoding Leu21-Lys414 is expressed with a 10His tag at the C-terminus.
Fusion Tag: C-His
Species: Human
Expressed Host: Human Cells
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Molecular Mass: 46.5 kDa
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH7.5.
Reconstitution: Not Applicable
Background: Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin has three β-sheets; nine α-helices; and one central loop; the structure is part of the set of distinctive features that are descriptive of Serpin family members. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat. and could be associated with parameters of obesity; insulin resistance; and glucose metabolism. These findings suggest a potential clinical use for Vaspin in ameliorating certain aberrations seen in the obesity metabolic syndrome.
Research Area: Signal Transduction, Cell biology, Cardiovascular, Neuroscience, Cancer, metabolism,
