Recombinant Human UROS/UROIIIS Protein (His Tag) | PKSH033200

Recombinant Human UROS/UROIIIS Protein (His Tag) | PKSH033200 | Gentaur US, UK & Europe Disrtribition

Synonyms: Uroporphyrinogen-III Synthase; UROIIIS; UROS; Hydroxymethylbilane Hydrolyase [Cyclizing]; Uroporphyrinogen-III Cosynthase; UROS

Active Protein: N/A

Activity: Recombinant Human Uroporphyrinogen-III Synthase is produced by our E.coli expression system and the target gene encoding Met1-Cys265 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Uroporphyrinogen-III Synthase is produced by our E.coli expression system and the target gene encoding Met1-Cys265 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 29.7 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 10% Glycerol, pH 8.0.

Reconstitution: Not Applicable

Background: Uroporphyrinogen-III Synthase is an enzyme which belongs to the uroporphyrinogen-III synthase family. Uroporphyrinogen-III Synthase is ubiquitous and it is involved in Porphyrin metabolism. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as Methionine synthesis (Vitamin B12) or oxygen transport (Heme). Uroporphyrinogen-III Synthase can catalyze cyclization of the linear Tetrapyrrole, Hydroxymethylbilane, to the Macrocyclic Uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of Porphyrins. Defects in Uroporphyrinogen-III Synthase are the cause of Congenital Erythropoietic Porphyria (CEP).

Research Area: Cell biology