Recombinant Human UROD Protein (His Tag) | PKSH033199

Recombinant Human UROD Protein (His Tag) | PKSH033199 | Gentaur US, UK & Europe Disrtribition

Synonyms: Uroporphyrinogen Decarboxylase; UPD; URO-D; UROD

Active Protein: N/A

Activity: Recombinant Human Uroporphyrinogen Decarboxylase is produced by our E.coli expression system and the target gene encoding Met1-Asn367 is expressed with a 6His tag at the N-terminus.

Protein Construction: Recombinant Human Uroporphyrinogen Decarboxylase is produced by our E.coli expression system and the target gene encoding Met1-Asn367 is expressed with a 6His tag at the N-terminus.

Fusion Tag: N-6His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 43.0 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, pH 8.0.

Reconstitution: Not Applicable

Background: Uroporphyrinogen decarboxylase (UROD), is an enzyme of the heme biosynthetic pathway which belongs to the uroporphyrinogen decarboxylase family. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. UROD is a homodimeric enzyme that catalyzes the fifth step in heme biosynthesis: the elimination of carboxyl groups from the four acetate side chains of uroporphyrinogen III to yield coproporphyrinogen III. Defects in UROD are the cause of familial porphyria cutanea tarda (FPCT) and hepatoerythropoietic porphyria (HEP).

Research Area: Cell biology, Cardiovascular