Recombinant Human UBE2D1 Protein (His Tag) | PKSH031122

Recombinant Human UBE2D1 Protein (His Tag) | PKSH031122 | Gentaur US, UK & Europe Disrtribition

Synonyms: Ubiquitin-conjugating enzyme E2 D1;Stimulator of Fe transport;SFT;UBC4/5 homolog;UbcH5;Ubiquitin carrier protein D1;Ubiquitin-conjugating enzyme E2(17)KB 1;Ubiquitin-conjugating enzyme E2-17 kDa 1;Ubiquitin-protein ligase D1;SFT; UBC5A; UBCH5; UBCH5A

Active Protein: N/A

Activity: A DNA sequence encoding the human UBE2D1 (P51668) (Ala 2-Met 147) was expressed; with a polyhistide tag at the N-terminus.

Protein Construction: A DNA sequence encoding the human UBE2D1 (P51668) (Ala 2-Met 147) was expressed; with a polyhistide tag at the N-terminus.

Fusion Tag: N-His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 18.3 kDa

Formulation: Lyophilized from sterile 25mM Tris, 100mM NaCl, 20% glycerol, 0.05% Tween

Reconstitution: Please refer to the printed manual for detailed information.

Background: Ubiquitin-conjugating enzyme E2 D1 (UBE2D1); a member of human E2 ubiquitin-conjugating enzymes; is closely related to SFT; which is short for stimulator of iron (Fe) transport. In other words; UbcH5A is significantly up-regulated in the liver of iron-overloaded patients with hereditary hemochromatosis; as previously published for SFT. Moreover; a complex of UBE2D1 is critical in maintaining KRAS protein stability and propose that targeting such complex may be a unique strategy to degrade mutant KRAS to kill cancer cells.

Research Area: Cell biology, epigenetics and nuclear signal