Recombinant Human Tyrosine-protein kinase receptor UFO/AXL oncogene/UFO (C-6His) | PKSH033929

Recombinant Human Tyrosine-protein kinase receptor UFO/AXL oncogene/UFO (C-6His) | PKSH033929 | Gentaur US, UK & Europe Disrtribition

Synonyms: Tyrosine-protein kinase receptor UFO; AXL oncogene; UFO

Active Protein: N/A

Activity: Recombinant Human Tyrosine-protein kinase receptor UFO is produced by our Mammalian expression system and the target gene encoding Ala26-Pro440 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Tyrosine-protein kinase receptor UFO is produced by our Mammalian expression system and the target gene encoding Ala26-Pro440 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 45.6 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl cytoplasmic domain. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is highly expressed in solid cancers and promotes in vivo tumorigenesis and tumor cell invasiveness. It also functions as a cellular entry receptor for Gas6-opsonized lentiviruses. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.

Research Area: N/A