Recombinant Human TRP1/TYRP1 Protein (Human Cells, His Tag) | PKSH030692

Recombinant Human TRP1/TYRP1 Protein (Human Cells, His Tag) | PKSH030692 | Gentaur US, UK & Europe Disrtribition

Synonyms: b-PROTEIN;CAS2;CATB;GP75;OCA3;TRP;TRP1;TYRP

Active Protein: N/A

Activity: A DNA sequence encoding the human TYRP1 (P17643) extracellular domain (Met 1- Arg 471) was fused with a polyhistidine tag at the C-terminus.

Protein Construction: A DNA sequence encoding the human TYRP1 (P17643) extracellular domain (Met 1- Arg 471) was fused with a polyhistidine tag at the C-terminus.

Fusion Tag: C-His

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 52.2 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Tyrosinase-related protein 1; also known as TYRP1 or TRP1; is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Mutations in this enzyme are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. TYRP1 / TRP1 is involved in the oxidation of 5;6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5;6-quinone-2-carboxylic acid. This enzyme may regulate or influence the type of melanin synthesized. The expression of Tyrosinase-related protein 1 (TYRP1) is regulated by the microphthalmia-associated transcription factor (MITF). There is mounting evidence demonstrating that in addition to its role in eumelanin synthesis; TYRP1 is involved in maintaining stability of tyrosinase proliferation and melanocyte cell death.

Research Area: Signal Transduction, Tags & Cell Markers, Cell biology, Cancer, epigenetics and nuclear signal, immunology, metabolism,