Description
Recombinant Human TRAIL R2/TNFRSF10B Protein (Fc & His Tag) | PKSH033127 | Gentaur US, UK & Europe Disrtribition
Synonyms: Tumor Necrosis Factor Receptor Superfamily Member 10B; Death Receptor 5; TNF-Related Apoptosis-Inducing Ligand Receptor 2; TRAIL Receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9
Active Protein: N/A
Activity: Recombinant Human TNF-Related Apoptosis-Inducing Ligand Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ile56-Glu182 is expressed with a Fc; 6His tag at the C-terminus.
Protein Construction: Recombinant Human TNF-Related Apoptosis-Inducing Ligand Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ile56-Glu182 is expressed with a Fc; 6His tag at the C-terminus.
Fusion Tag: C-Fc-6His
Species: Human
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 42.2 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: TNFRSF10B is a member of the TNF-receptor superfamily; and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L); and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types; and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region; followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.
Research Area: Signal Transduction, Cell biology, Cardiovascular, Cancer,
