Recombinant Human TNFRSF19/TROY Protein (Fc Tag) | PKSH030639

Recombinant Human TNFRSF19/TROY Protein (Fc Tag) | PKSH030639 | Gentaur US, UK & Europe Disrtribition

Synonyms: TAJ;TAJ-alpha;TNFRSF19;TRADE;TROY

Active Protein: N/A

Activity: A DNA sequence encoding the human TNFRSF19 (Q9NS68-2) (Met1-Leu170) was expressed; fused with the Fc region of human IgG1 at the C-terminus.

Protein Construction: A DNA sequence encoding the human TNFRSF19 (Q9NS68-2) (Met1-Leu170) was expressed; fused with the Fc region of human IgG1 at the C-terminus.

Fusion Tag: C-Fc

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 42.5 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Tumor necrosis factor receptor superfamily; member 19 (TNFRSF19); also known as TAJ-alpha or TROY; is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the ductal epithelium of the prostate and parotid glands. TNFRSF19/TROY expression is detected in some adenocarcinoma cell lines that arise from this tissue. It has been shown to interact with TRAF family members; and to activate JNK signaling pathway when overexpressed in cells. TNFRSF19/TROY is capable of inducing apoptosis by a caspase-independent mechanism; and it is thought to play an essential role in embryonic development. TNFRSF19/TROY was negatively regulated by adipogenic transcription factor CCAAT/enhancer-binding proteins (C/EBP). TNFRSF19 signals activation of the Jnk pathway and induces cell death. Overexpression of TNFRSF19 also signals NFB activation; comparable and similar to that by p75NGFR. TNFRSF19/TROY is capable of activating key signaling pathways of the TNF receptor family; and its predominant expression patterns suggest that it plays a role in the growth and regulation of epithelial tissues.

Research Area: N/A