Recombinant Human Tie1 Protein (His Tag) | PKSH033171

Recombinant Human Tie1 Protein (His Tag) | PKSH033171 | Gentaur US, UK & Europe Disrtribition

Synonyms: Tyrosine-Protein Kinase Receptor Tie-1; TIE1; TIE

Active Protein: N/A

Activity: Recombinant Human Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains 1 is produced by our Mammalian expression system and the target gene encoding Ala22-Gln760 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains 1 is produced by our Mammalian expression system and the target gene encoding Ala22-Gln760 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 81.0 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.

Reconstitution: Please refer to the printed manual for detailed information.

Background: TIE-1 (Tyrosine Kinase with Ig and EGF Homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily. These receptors are expressed on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18aa signal peptide, a 727 aa extracellular domain and a 354 aa cytoplasmic domain. so far, two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], but no ligand was found for TIE-1.

Research Area: Signal Transduction, Cardiovascular, Cancer, Developmental Biology, Stem cells