Recombinant Human Thymidylate Kinase/DTYMK Protein (His Tag) | PKSH033115

Recombinant Human Thymidylate Kinase/DTYMK Protein (His Tag) | PKSH033115 | Gentaur US, UK & Europe Disrtribition

Synonyms: Thymidylate kinase;dTMP kinase;DTYMK;CDC8; TMPK; TYMK

Active Protein: N/A

Activity: Recombinant Human Thymidylate kinase is produced by our Mammalian expression system and the target gene encoding Met1-Lys212 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Thymidylate kinase is produced by our Mammalian expression system and the target gene encoding Met1-Lys212 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 24.9 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.

Reconstitution: Not Applicable

Background: Thymidylate kinase (DTYMK) is a ubiquitous enzyme of about 25 kD which belongs to thymidylate kinase family. DTYMK is important in the dTTP synthesis pathway for DNA synthesis. It participated in the pyrimidine metabolism pathway and dTTP biosynthesis pathway. DTYMK catalyzes the conversion of dTMP to dTDP and catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium. Structural and functional analyses suggest that the cDNA codes for authentic human dTMP kinase. The mRNA levels and enzyme activities corresponded to cell cycle progression and cell growth stages.

Research Area: epigenetics and nuclear signal