Description
Recombinant Human TCPTP/PTPN2 (C-6His) | PKSH033981 | Gentaur US, UK & Europe Disrtribition
Synonyms: PTP2; PTPN2; PTPTPTN2; TCELLPTP; TCPTP; TC-PTP
Active Protein: N/A
Activity: Recombinant Human Tyrosine-protein phosphatase non-receptor type 2 is produced by our E.coli expression system and the target gene encoding Thr2-Asn314 is expressed with a 6His tag at the C-terminus.
Protein Construction: Recombinant Human Tyrosine-protein phosphatase non-receptor type 2 is produced by our E.coli expression system and the target gene encoding Thr2-Asn314 is expressed with a 6His tag at the C-terminus.
Fusion Tag: C-6His
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Molecular Mass: 37.4 kDa
Formulation: Supplied as a 0.2 μm filtered solution of 20mM HEPES, 300Mm NaCl, 1mM DTT, 10% Glycerol, pH 7.4.
Reconstitution: Not Applicable
Background: Tyrosine-protein phosphatase non-receptor type 2 (PTPN2), also known as PTPT and TC-PTP, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. Members of the protein tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP / PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP / PTPN2 plays a role of tumor suppressor and may modulate response to treatment. TC-PTP / PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation.TC-PTP / PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.
Research Area: Signal Transduction,
