Recombinant Human SULT1B1 Protein (His Tag)(Active) | PKSH031074

Recombinant Human SULT1B1 Protein (His Tag)(Active) | PKSH031074 | Gentaur US, UK & Europe Disrtribition

Synonyms: Sulfotransferase Family Cytosolic 1B Member 1; ST1B1; Sulfotransferase 1B1; Sulfotransferase 1B2; ST1B2; Thyroid Hormone Sulfotransferase; SULT1B1; ST1B2; SULT1B2

Active Protein: Active protein

Activity: A DNA sequence encoding the human SULT1B1 (NP_055280.2) (Leu 2-Ile 296) was expressed; with a N-terminal polyhistidine tag.

Protein Construction: A DNA sequence encoding the human SULT1B1 (NP_055280.2) (Leu 2-Ile 296) was expressed; with a N-terminal polyhistidine tag.

Fusion Tag: N-His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 35.7 kDa

Formulation: Lyophilized from sterile 20mM Tris, 0.1 M NaCl, 10% glycerol, 1mM DTT, pH 8.0

Reconstitution: Please refer to the printed manual for detailed information.

Background: Sulfotransferase family cytosolic 1B member 1; also known as Sulfotransferase 1B1; Sulfotransferase 1B2; Thyroid hormone sulfotransferase; SULT1B1 and ST1B2; is a cytoplasm protein which belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones; neurotransmitters; drugs; and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1B1 is highly expressed in the liver; peripheral blood leukocytes; colon (mucosal lining); small intestine (jejunum) and spleen. A lesser expression of SULT1B1 was observed in the lung; placenta and thymus. SULT1B1 catalyzes the sulfate conjugation of many hormones; neurotransmitters; drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds; and therefore their renal excretion; but it can also result in bioactivation to form active metabolites. SULT1B1 sulfates dopamine; small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones; including 3;3'-diiodothyronine; triidothyronine; reverse triiodothyronine and thyroxine.

Research Area: Signal Transduction, Cancer, metabolism,