Recombinant Human SORD Protein (His Tag) | PKSH033074

Recombinant Human SORD Protein (His Tag) | PKSH033074 | Gentaur US, UK & Europe Disrtribition

Synonyms: Sorbitol Dehydrogenase; L-Iditol 2-Dehydrogenase; SORD

Active Protein: N/A

Activity: Recombinant Human Sorbitol Dehydrogenase is produced by our Mammalian expression system and the target gene encoding Ala2-Pro357 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Sorbitol Dehydrogenase is produced by our Mammalian expression system and the target gene encoding Ala2-Pro357 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 39.3 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 0.2M NaCl, 5mM DTT, 20% glycerol, pH8.0.

Reconstitution: Not Applicable

Background: Sorbitol dehydrogenase, also known as L-iditol 2-dehydrogenase and SORD, is a member of the zinc-containing alcohol dehydrogenase family. SORD exsits in a homotetramer and binds one zinc ion per subunit. SORD is expressed in kidney and epithelial cells of both benign and malignant prostate tissue. SORD can converts sorbitol to fructose and catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase to make up the sorbitol pathway. SORD is up-regulated by androgens and down-regulated by castration. SORD may play a role in the sperm motility by providing an energetic source for sperm.

Research Area: Signal Transduction, metabolism,