Recombinant Human SLPI Protein (aa 1-132, His Tag)(Active) | PKSH031665

Recombinant Human SLPI Protein (aa 1-132, His Tag)(Active) | PKSH031665 | Gentaur US, UK & Europe Disrtribition

Synonyms: ALK1;ALP;BLPI;HUSI;HUSI-I;MPI;WAP4;WFDC4

Active Protein: Active protein

Activity: A DNA sequence encoding the human SLPI (P03973)( Met1-Ala132) was expressed; with a C-terminal polyhistidine tag.

Protein Construction: A DNA sequence encoding the human SLPI (P03973)( Met1-Ala132) was expressed; with a C-terminal polyhistidine tag.

Fusion Tag: C-His

Species: Human

Expressed Host: Baculovirus-Insect Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 13.1 kDa

Formulation: Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% gly, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Secretory leukoprotease inhibitor (SLPI); also called antileukoprotease (ALP); is a 12-kDa; nonglycosylated serine protease inhibitor present in mucous secretions. It is thought to play a role in protecting the mucosae from injury associated with inflammation. SLPI is locally produced by serous cells; including bronchial submucosal glands. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites; and have been shown to be modulated in multiple pathological conditions. Elafin and SLPI are structurally related in that both have a fold with a four-disulfide core or whey acidic protein (WAP) domain responsible for inhibiting proteases. SLPI is a prominent innate immune protein of the respiratory tract; possessing serine protease inhibitor activity; antibacterial activity; and anti-inflammatory/immunomodulatory activity.

Research Area: Cell biology, Cardiovascular, immunology