Description
Recombinant Human SLAMF6/Ly108 Protein (aa 1-226, His Tag)(Active) | PKSH030961 | Gentaur US, UK & Europe Disrtribition
Synonyms: SLAM Family Member 6; Activating NK Receptor; NK-T-B-Antigen; NTB-A; CD352; SLAMF6; KALI; Ly108; NTBA; SF2000
Active Protein: Active protein
Activity: A DNA sequence encoding the human SLAMF6 (Q96DU3-1) extracellular domain (Met 1-Met 226) was expressed; with a polyhistidine tag at the C-terminus.
Protein Construction: A DNA sequence encoding the human SLAMF6 (Q96DU3-1) extracellular domain (Met 1-Met 226) was expressed; with a polyhistidine tag at the C-terminus.
Fusion Tag: C-His
Species: Human
Expressed Host: HEK293 Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 24.3 kDa
Formulation: Lyophilized from sterile PBS, pH 7.4
Reconstitution: Please refer to the printed manual for detailed information.
Background: SLAM family member 6; also known as Activating NK receptor; NK-T-B-antigen; NTB-A; SLAMF6; KALI and Ly108; is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK); T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and; upon phosphorylation; with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.
Research Area: N/A
