Recombinant Human S100A8&S100A9 Heterodimer Protein (His Tag) | PKSH033381

Recombinant Human S100A8&S100A9 Heterodimer Protein (His Tag) | PKSH033381 | Gentaur US, UK & Europe Disrtribition

Synonyms: S100A8/S100A9 Heterodimer

Active Protein: N/A

Activity: Recombinant Human S100 Calcium Binding Protein S100A8/S100A9 Heterodimer is produced by our E.coli expression system and the target gene encoding Met1-Glu93(S100A8)&Thr2-Pro114(S100A9) is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human S100 Calcium Binding Protein S100A8/S100A9 Heterodimer is produced by our E.coli expression system and the target gene encoding Met1-Glu93(S100A8)&Thr2-Pro114(S100A9) is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 11.7&13.2 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM HEPES, 10%Glycerol, 150mM NaCl, 2.5mM EDTA, pH 7.4.

Reconstitution: Not Applicable

Background: S100A8 is a member of the S100 family, EF-hand superfamily of Ca-binding proteins. It is produced by neutrophils and monocytes, and forms Ca2+-dependent heterodimer/heterotetramer complexes (termed calprotectin) with S100A9. Calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.

Research Area: Signal Transduction, Cell biology, Neuroscience, Cancer, epigenetics and nuclear signal, immunology