Recombinant Human S100A2 Protein (Fc Tag) | PKSH031791

Recombinant Human S100A2 Protein (Fc Tag) | PKSH031791 | Gentaur US, UK & Europe Disrtribition

Synonyms: Protein S100-A2; CAN19; Protein S-100L; S100 calcium-binding protein A2; S100A2; S100L

Active Protein: N/A

Activity: A DNA sequence encoding the human S100A2 (NP_005969.1) (Met 2-Pro98) was expressed with the fused Fc region of human IgG1 at the N-terminus.

Protein Construction: A DNA sequence encoding the human S100A2 (NP_005969.1) (Met 2-Pro98) was expressed with the fused Fc region of human IgG1 at the N-terminus.

Fusion Tag: N-Fc

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 37.6 kDa

Formulation: Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5

Reconstitution: Please refer to the printed manual for detailed information.

Background: The calcium-binding Protein S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family genes are located as a cluster on chromosome 1q21; and S100 proteins consisting of at least 20 members are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. S100A2 was first detected in lung and kidney; and is mainly expressed in a subset of tissues and cells such as breast epithelia and liver. The S100A2 protein is a homodimer that undergoes a conformational change upon binding of calcium; and the active form functions in regulating cell proliferation and differentiation; gene transcription; and p53-dependent growth arrest and apoptosis. Accordingly; this protein is regarded as a putative tumor suppressor; and thus chromosomal rearrangements and reduced expression of S100A2 gene have been implicated in certain carcinomas.

Research Area: Signal Transduction, Cell biology,