Recombinant Human ROR1 Protein (Fc Tag) | PKSH033648

Recombinant Human ROR1 Protein (Fc Tag) | PKSH033648 | Gentaur US, UK & Europe Disrtribition

Synonyms: Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase; receptor-related 1; ROR1; NTRKR1

Active Protein: N/A

Activity: Recombinant Human ROR1 is produced by our Mammalian expression system and the target gene encoding Gln30-Glu403 is expressed with a Fc tag at the C-terminus.

Protein Construction: Recombinant Human ROR1 is produced by our Mammalian expression system and the target gene encoding Gln30-Glu403 is expressed with a Fc tag at the C-terminus.

Fusion Tag: C-Fc

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 68.9 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: CD217; also known as Interleukin-17 receptor A; is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F; it binds to IL17A with higher affinity than to IL17F and binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. It also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. The activation of IL17RA would lead to induction of expression of inflammatory chemokines and cytokines such as CXCL1; CXCL8/IL8 and IL6. The signaling events of IL 17 includes activation of NF kappa B and JNK; and require TNF receptor associated factors 6 (TRAF6) in the signaling pathway.

Research Area: Signal Transduction, Neuroscience,