Recombinant Human ROR1 Protein (aa 453-783, His & GST Tag)(Active) | PKSH030321

Recombinant Human ROR1 Protein (aa 453-783, His & GST Tag)(Active) | PKSH030321 | Gentaur US, UK & Europe Disrtribition

Synonyms: dJ537F10.1;NTRKR1

Active Protein: Active protein

Activity: A DNA sequence encoding the human ROR1 (AAA60275.1) (Met453-Asn783) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Protein Construction: A DNA sequence encoding the human ROR1 (AAA60275.1) (Met453-Asn783) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Fusion Tag: N-His & GST

Species: Human

Expressed Host: Baculovirus-Insect Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 65.3 kDa

Formulation: Supplied as sterile 20mM Tris, 500mM NaCl, 2mM GSH, 3mM DTT, 10% glycerol, pH 7.4

Reconstitution: Not Applicable

Background: Receptor tyrosine kinase-like orphan receptor 1 (ROR1), also known as neurotrophic tyrosine kinase, it is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily. Human ROR1 is a type I transmembrane protein with 937 amino acids (aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. At developmental stage, it expressed at high levels during early embryonic development. ROR1 has been shown to have very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

Research Area: N/A