Recombinant Human RELT/TNFRSF19L Protein (His & Fc Tag) | PKSH031544

Recombinant Human RELT/TNFRSF19L Protein (His & Fc Tag) | PKSH031544 | Gentaur US, UK & Europe Disrtribition

Synonyms: Tumor necrosis factor receptor superfamily member 19L; TNFRSF19L; Receptor expressed in lymphoid tissues; RELT

Active Protein: N/A

Activity: A DNA sequence encoding the human RELT (NP_116260.2) extracellular domain (Met 1-Ala 160) with 127R/G & 129R/G mutation was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Protein Construction: A DNA sequence encoding the human RELT (NP_116260.2) extracellular domain (Met 1-Ala 160) with 127R/G & 129R/G mutation was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Fusion Tag: C-His & Fc

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 42 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Receptor expressed in lymphoid tissues (RELT); also known as tumor necrosis factor receptor superfamily; member 19-like (TNFRSF19L); is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1. RELT/TNFRSF19L is capable of stimulating T-cell proliferation in the presence of CD3 signaling; which suggests its regulatory role in immune response. RELT/TNFRSF19L is a type I transmembrane glycoprotein with a cysteine-rich extracellular domain; possessing significant homology to other members of the TNFR superfamily; especially TNFRSF19; DR3; OX40; and LTbeta receptor. RELT/TNFRSF19L is able to activate the NF-kappaB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. RELT/TNFRSF19L is able to activate the NF-κB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. Although the soluble form of RELT fusion protein does not inhibit the one-way mixed lymphocyte reaction; immobilized RELT/TNFRSF19L is capable of costimulating T-cell proliferation in the presence of CD3 signaling.

Research Area: Signal Transduction,