Recombinant Human RAC2 Protein (His Tag) | PKSH030903

Recombinant Human RAC2 Protein (His Tag) | PKSH030903 | Gentaur US, UK & Europe Disrtribition

Synonyms: EN-7;Gx;HSPC022;p21-Rac2

Active Protein: N/A

Activity: A DNA sequence encoding the human RAC2 (P15153) (Met 1-Cys 189) was expressed, with a polyhistidine tag at the N-terminus.

Protein Construction: A DNA sequence encoding the human RAC2 (P15153) (Met 1-Cys 189) was expressed, with a polyhistidine tag at the N-terminus.

Fusion Tag: N-His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 94 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 22.6 kDa

Formulation: Lyophilized from sterile PBS, 20% glycerol, pH 7.5

Reconstitution: Please refer to the printed manual for detailed information.

Background: Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is attached to the small G-protein, the enzyme is inactivated. Release of the GDP and replace of the GTP cativate the GTPasee. Rac2 remains active until the GTP is hydrolyzed to GDP. Rac2 is a hematopoietic-specific Rho family GTPase implicated as an important constituent of the NADPH oxidase complex and shares 92% amino acid identity with the ubiquitously expressed Rac1. The small G-protein Rac2 regulates the rearrangements of actin and membrane necessary for Fcy receptor-mediated phagocytosis by macrophages. Activated Rac2 binds to the p21-binding domain of PAK1 and this binding provided a basis for microscopic methods to localize activation of these G proteins inside cells.

Research Area: Signal Transduction,