Recombinant Human PSMA Protein (His Tag) | PKSH033667

Recombinant Human PSMA Protein (His Tag) | PKSH033667 | Gentaur US, UK & Europe Disrtribition

Synonyms: Glutamate carboxypeptidase 2; FGCP; GCPII; mGCP; NAALADase I; PSMA; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; FOLH1; GCP2; FGCP; GCPII; Mgcp; NAALADase I;FOLH;mGCP;NAALAD1;NAALAdase;PSM;PSMA

Active Protein: N/A

Activity: Recombinant Human PSMA is produced by our Mammalian expression system and the target gene encoding Lys44-Ala750 is expressed with a 6His tag at the N-terminus.

Protein Construction: Recombinant Human PSMA is produced by our Mammalian expression system and the target gene encoding Lys44-Ala750 is expressed with a 6His tag at the N-terminus.

Fusion Tag: N-His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 80.6 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mMMES，150mMNacl，5% Trehalose，pH5.5.

Reconstitution: Not Applicable

Background: Glutamate carboxypeptidase 2, also known as FOLH1, PSMA, belongs to the M28B subfamily and the peptidase M28 family. It is highly expressed in prostate epithelium and can be detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker for various neurological disorders such as schizophrenia, Alzheimer disease and Huntington disease. It has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. PSMA involves in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, PSMA cleaves Gly-Pro-AMC. PSMA is stable at pH greater than 6.5.

Research Area: Signal Transduction, Cancer, metabolism,