Recombinant Human PSA/KLK3 Protein (aa 25-261, His Tag) | PKSH032949

Recombinant Human PSA/KLK3 Protein (aa 25-261, His Tag) | PKSH032949 | Gentaur US, UK & Europe Disrtribition

Synonyms: APS;Hk3;KLK2A1;PSA;Prostate-Specific Antigen; PSA; Gamma-Seminoprotein; Seminin; Kallikrein-3; P-30 Antigen; Semenogelase;

Active Protein: N/A

Activity: Recombinant Human Kallikrein-3/Prostate-specific antigen is produced by our Mammalian expression system and the target gene encoding Ile25-Pro261 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Kallikrein-3/Prostate-specific antigen is produced by our Mammalian expression system and the target gene encoding Ile25-Pro261 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 27.1 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM TrisHcl, 150mM NaCl, 1mM CaCl2, pH7.5.

Reconstitution: Not Applicable

Background: KLK3; also known as APS; is short for Prostate-specific antigen. It is a 261 aa. protein which belongs to the peptidase S1 family and Kallikrein subfamily. This protein has 5 isforms produced by alternative splicing. It is a secreted protein and can forms a heterodimer with SERPINA5 which can inhibit its activity. KLK3 is also strongly inhibited by Zn2+; 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins; which are avid zinc binders. KLK3 can hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Research Area: Signal Transduction, Tags & Cell Markers, Neuroscience, Cancer, immunology,