Recombinant Human Pro-Neuregulin-1/NRG1-‑β1 Protein (aa 1-246, His Tag)(Active) | PKSH032940

Recombinant Human Pro-Neuregulin-1/NRG1-‑β1 Protein (aa 1-246, His Tag)(Active) | PKSH032940 | Gentaur US, UK & Europe Disrtribition

Synonyms: Pro-neuregulin-1;Neuregulin-1 beta 1;NRG1-beta 1;HRG1-beta 1; EGF;NRG1; GGF; HGL; HRGA; NDF; SMDF;

Active Protein: Active protein

Activity: Recombinant Human Neuregulin-1 beta is produced by our E.coli expression system and the target gene encoding Met1-Lys246 is expressed with a 6His tag at the N-terminus.

Protein Construction: Recombinant Human Neuregulin-1 beta is produced by our E.coli expression system and the target gene encoding Met1-Lys246 is expressed with a 6His tag at the N-terminus.

Fusion Tag: N-6His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 29.0 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of 4mM HCl.

Reconstitution: Please refer to the printed manual for detailed information.

Background: neuregulin-1 (heregulin-1;NRG1) is a member of neuregulin family; which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I; type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors; concomitantly recruits ERBB1 and ERBB2 coreceptors; resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.

Research Area: N/A