Description
Recombinant Human POLD2 Protein (His Tag) | PKSH032361 | Gentaur US, UK & Europe Disrtribition
Synonyms: DNA Polymerase Delta Subunit 2; DNA Polymerase Delta Subunit p50; POLD2
Active Protein: N/A
Activity: Recombinant Human DNA Polymerase Delta Subunit 2 is produced by our E.coli expression system and the target gene encoding Met1-Pro469 is expressed with a 6His tag at the C-terminus.
Protein Construction: Recombinant Human DNA Polymerase Delta Subunit 2 is produced by our E.coli expression system and the target gene encoding Met1-Pro469 is expressed with a 6His tag at the C-terminus.
Fusion Tag: C-6His
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Molecular Mass: 52.3 kDa
Formulation: Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
Reconstitution: Not Applicable
Background: DNA Polymerase Delta Subunit 2 (POLD2) belongs to the DNA polymerase delta/II small subunit family. POLD2 can form a heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. POLD2 possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. POLD2 is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA).
Research Area: epigenetics and nuclear signal
