Recombinant Human Phosphomevalonate Kinase/PMVK Protein (His Tag) | PKSH032895

Recombinant Human Phosphomevalonate Kinase/PMVK Protein (His Tag) | PKSH032895 | Gentaur US, UK & Europe Disrtribition

Synonyms: Phosphomevalonate Kinase; PMKase; hPMK; PMVK; PMKI

Active Protein: N/A

Activity: Recombinant Human Phosphomevalonate Kinase is produced by our E.coli expression system and the target gene encoding Met1-Leu192 is expressed with a 6His tag at the N-terminus.

Protein Construction: Recombinant Human Phosphomevalonate Kinase is produced by our E.coli expression system and the target gene encoding Met1-Leu192 is expressed with a 6His tag at the N-terminus.

Fusion Tag: N-6His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 24.2 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 10% Glycerol, pH 7.5.

Reconstitution: Not Applicable

Background: Phosphomevalonate kinase (PMVK) is a cytosolic enzyme. PMVK can be highly expressed in the heart, skeletal muscle, liver, pancreas, and kidney; it is expressed at lower levels in the brain, lung, and placenta. Induced by sterol, PMVK takes part in isopentenyl diphosphate biosynthesis through the mevalonate pathway. PMVK catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate in the fifth reaction of the cholesterol biosynthetic pathway.

Research Area: Signal Transduction, Cancer, metabolism,