Recombinant Human PFKFB1 Protein (His Tag) | PKSH032459

Recombinant Human PFKFB1 Protein (His Tag) | PKSH032459 | Gentaur US, UK & Europe Disrtribition

Synonyms: 6-phosphofructo-2-kinase/fructose-2;6-bisphosphatase 1; 6PF-2-K/Fru-2;6-P2ase liver isozyme; Fructose-2;6-bisphosphatase; PFKFB1; F6PK; PFRX

Active Protein: N/A

Activity: Recombinant Human 6-Phosphofructo-2-kinase/Fructose-2, 6-bisphosphatase 1 is produced by our Mammalian expression system and the target gene encoding Ser2-Tyr471 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human 6-Phosphofructo-2-kinase/Fructose-2, 6-bisphosphatase 1 is produced by our Mammalian expression system and the target gene encoding Ser2-Tyr471 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 55.6 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.

Reconstitution: Not Applicable

Background: 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2, 6-biphosphate using independent catalytic domains. It belongs to the phosphoglycerate mutase family. Fructose-2, 6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2, 6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.

Research Area: Signal Transduction, Cardiovascular, Neuroscience, Cancer, metabolism,