Recombinant Human PD-1/PDCD1 Protein (C93S Mutant, His Tag) | PKSH032862

Recombinant Human PD-1/PDCD1 Protein (C93S Mutant, His Tag) | PKSH032862 | Gentaur US, UK & Europe Disrtribition

Synonyms: Programmed cell death protein 1;PDCD1;PD-1;hPD-1;CD279;SLEB2;Hsle1

Active Protein: N/A

Activity: Recombinant Human Programmed Cell Death Protein 1 mutant(C93S) is produced by our Mammalian expression system and the target gene encoding Leu25-Gln167;Cys93Ser is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Programmed Cell Death Protein 1 mutant(C93S) is produced by our Mammalian expression system and the target gene encoding Leu25-Gln167;Cys93Ser is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 16.8 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1; IL-4; IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition; coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance; and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule; PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation; cytokine production; and cytolytic function.

Research Area: Cell biology, Cancer, immunology