Recombinant Human OX-2/MOX1/CD200 Protein (Fc Tag) | PKSH032841

Recombinant Human OX-2/MOX1/CD200 Protein (Fc Tag) | PKSH032841 | Gentaur US, UK & Europe Disrtribition

Synonyms: OX-2 Membrane Glycoprotein; CD200; MOX1; MOX2

Active Protein: N/A

Activity: Recombinant Human CD200 is produced by our Mammalian expression system and the target gene encoding Gln31-Gly232 is expressed with a Fc tag at the C-terminus.

Protein Construction: Recombinant Human CD200 is produced by our Mammalian expression system and the target gene encoding Gln31-Gly232 is expressed with a Fc tag at the C-terminus.

Fusion Tag: C-Fc

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 49.5 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: CD200 is a transmembrane immunoregulatory protein that belongs to the immunoglobulin superfamily. It contains one Ig like V type domain and one Ig like C2 type domain in its extracelluar domain. CD200 is widely but not ubiquitously expressed. Its receptor (CD200R) is restricted primarily to mast cells; basophils; macrophages; and dendritic cells; which suggests myeloid cell regulation as the major function of CD200. CD200 and CD200R associate via their respective N-terminal Ig-like domains. In myeloid cells; CD200R initiates inhibitory signals following receptor-ligand contact. In T cells; CD200 functions as a co-stimulatory molecule independent of the CD28 pathway. In addition; CD200 also plays an important role in prevention of graft rejection; autoimmune diseases and spontaneous abortion.

Research Area: Cardiovascular, immunology