Description
Recombinant Human OMGP/OMG Protein (aa 1-420, His Tag)(Active) | PKSH031717 | Gentaur US, UK & Europe Disrtribition
Synonyms: OMGP
Active Protein: Active protein
Activity: A DNA sequence encoding the mature form of human OMGP (P23515-1) (Met 1-Asn 420) without the pro peptide was expressed; fused with a polyhistidine tag at the C-terminus.
Protein Construction: A DNA sequence encoding the mature form of human OMGP (P23515-1) (Met 1-Asn 420) without the pro peptide was expressed; fused with a polyhistidine tag at the C-terminus.
Fusion Tag: C-His
Species: Human
Expressed Host: HEK293 Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 97 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 46 kDa
Formulation: Lyophilized from sterile PBS, pH 7.4
Reconstitution: Please refer to the printed manual for detailed information.
Background: Oligodendrocyte-myelin glycoprotein; also known as OMG and OMGP; is a cell membrane protein which contains eight LRR (leucine-rich) repeats. OMG / OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG / OMGP is a cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. OMG / OMGP play roles in both the developing and adult central nervous system. OMG / OMGP participats in growth cone collapse and inhibition of neurite outgrowth through its interaction with NgR; the receptor for Nogo. This function requires its leucine-rich repeat domain; a highly conserved region in OMgp during mammal evolution. OMG / OMGP leucine-rich repeat domain is also implicated in the inhibition of cell proliferation. OMG / OMGP may also be involved in the formation and maintenance of myelin sheaths. Cell proliferation; neuronal sprouting and myelination are crucial processes involved in brain development and regeneration after injury.
Research Area: N/A
