Description
Recombinant Human OLR1/LOX1 Protein (His Tag) | PKSH033571 | Gentaur US, UK & Europe Disrtribition
Synonyms: Oxidized Low-Density Lipoprotein Receptor 1; Ox-LDL Receptor 1; C-Type Lectin Domain Family 8 Member A; Lectin-Like Oxidized LDL Receptor 1; LOX-1; Lectin-Like oxLDL Receptor 1; hLOX-1; Lectin-Type Oxidized LDL Receptor 1; OLR1; CLEC8A; LOX1;LOXIN;SCARE1;SLOX1
Active Protein: N/A
Activity: Recombinant Human LOX-1 is produced by our Mammalian expression system and the target gene encoding Ser61-Gln273 is expressed with a 6His tag at the C-terminus.
Protein Construction: Recombinant Human LOX-1 is produced by our Mammalian expression system and the target gene encoding Ser61-Gln273 is expressed with a 6His tag at the C-terminus.
Fusion Tag: C-His
Species: Human
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 25.39 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Oxidized Low-Density Lipoprotein Receptor 1 (Ox-LDL Receptor 1) is a secreted; single-pass type II membrane protein which belongs to the C-type lectin superfamily. Ox-LDL Receptor 1 is expressed at high levels in endothelial cells and vascular-rich organs such as placenta; lung; liver; brain; aortic intima; bone marrow; spinal cord and substantia nigra. The expression of Ox-LDL Receptor 1 is induced by inflammatory cytokines such as TNF; IFNG and IL6 by pathological conditions; such as hyperlipidemia; hypertension and diabetes mellitus. Ox-LDL Receptor 1 mediates the recognition; internalization and degradation of oxidatively modified low density lipoprotein (OxLDL) by vascular endothelial cells. Ox-LDL Receptor 1 association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release; monocyte adhesion and apoptosis. Ox-LDL Receptor 1 also binds to oxLDL; which acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells; thereby participating in cell-mediated antigen cross-presentation. It also participates in inflammatory process; by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
Research Area: Cardiovascular, Cancer, metabolism
