Description
Recombinant Human NGAL/Lipocalin-2 Protein (His Tag, E.coli) | PKSH032807 | Gentaur US, UK & Europe Disrtribition
Synonyms: Neutrophil gelatinase-associated lipocalin; NGAL; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25; HNL; NGAL
Active Protein: N/A
Activity: Recombinant Human Neutrophil gelatinase-associated lipocalin is produced by our E.coli expression system and the target gene encoding Gln21-Gly198 is expressed with a 6His tag at the C-terminus.
Protein Construction: Recombinant Human Neutrophil gelatinase-associated lipocalin is produced by our E.coli expression system and the target gene encoding Gln21-Gly198 is expressed with a 6His tag at the C-terminus.
Fusion Tag: C-6His
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Molecular Mass: 21.8 kDa
Formulation: Supplied as a 0.2 μm filtered solution of PBS, 50% glycerol, pH7.4.
Reconstitution: Not Applicable
Background: Neutrophil gelatinase-associated lipocalin(LCN2) is a secreted protein and belongs to the calycin superfamily. This protein is released from injured tubular cells after various damaging stimuli; is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover; recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores; which are high-affinity iron chelators. NGAL; first known as an antibacterial factor of natural immunity; and an acute phase protein; is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation; NGAL has a clear pro-tumoral effect; as has already been observed in different tumors (e.g. breast; stomach; oesophagus; brain) in humans. In thyroid carcinomas; NGAL is strongly induced by NF-kB; an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus; Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation; proliferation; survival and morphogenesis.
Research Area: Signal Transduction, Cardiovascular, Cancer, immunology, metabolism,
