Recombinant Human MTHFS Protein (His Tag) | PKSH032029

Recombinant Human MTHFS Protein (His Tag) | PKSH032029 | Gentaur US, UK & Europe Disrtribition

Synonyms: 5-formyltetrahydrofolate cyclo-ligase;5, 10-methenyl-tetrahydrofolate synthetase;MTHFS;Methenyl-THF synthetase

Active Protein: N/A

Activity: Recombinant Human 5-formyltetrahydrofolate cyclo-ligase is produced by our E.coli expression system and the target gene encoding Met1-Ala203 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human 5-formyltetrahydrofolate cyclo-ligase is produced by our E.coli expression system and the target gene encoding Met1-Ala203 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 24.3 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 200mM Nacl, 1mM DTT, 50% Glycerol, pH 8.0.

Reconstitution: Not Applicable

Background: 5-formyltetrahydrofolate cyclo-ligase (MTHFS) belongs to the 5-formyltetrahydrofolate cyclo-ligase family. It is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5, 10-methenyltetrahydrofolate, contributes to tetrahydrofolate metabolism. MTHFS helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion.

Research Area: Signal Transduction, Cancer, metabolism,