Description
Recombinant Human MKK6 Protein (207 Ser/Asp, 211 Thr/Asp, His & GST Tag)(Active) | PKSH030414 | Gentaur US, UK & Europe Disrtribition
Synonyms: MAPKK6;MEK6;MKK6;PRKMK6;SAPKK-3;SAPKK3;MAP2K6
Active Protein: Active protein
Activity: A DNA sequence encoding the human MAP2K6 isoform 1 (P52564-1) (Met 1-Asp 334; Ser 207/Asp; Thr 211/Asp) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Protein Construction: A DNA sequence encoding the human MAP2K6 isoform 1 (P52564-1) (Met 1-Asp 334; Ser 207/Asp; Thr 211/Asp) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Fusion Tag: N-His & GST
Species: Human
Expressed Host: Baculovirus-Insect Cells
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Purity: > 88 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Molecular Mass: 65.3 kDa
Formulation: Supplied as sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% glycerol
Reconstitution: Not Applicable
Background: Dual specificity mitogen-activated protein kinase kinase 6; also known as MAP kinase kinase 6; MAPKK 6; MAPK / ERK kinase 6; SAPKK3; MAP2K6 and MKK6; is a protein which belongs to the?protein kinase superfamily; STE Ser / Thr protein kinase family and MAP kinase kinase subfamily. MAP2K6 / MKK6 contains one?protein kinase domain. Mitogen-activated protein kinases are members of a conserved cascade of kinases involved in many signal transduction pathways. They stimulate phosphorylation of transcription factors in response to extracellular signals such as growth factors; cytokines; ultraviolet light; and stress-inducing agents. MAP2K6 / MKK6 exists in a variety of alternatively spliced isoforms with distinct patterns of tissue expression. Isoform 2 of MAP2K6 / MKK6 is only expressed in skeletal muscle. Isoform 1 of MAP2K6 / MKK6 is expressed in skeletal muscle; heart; and in lesser extent in liver or pancreas.
Research Area: N/A
