Description
Recombinant Human Mitochondrial Fission 1 Protein/FIS1 Protein (His Tag) | PKSH032758 | Gentaur US, UK & Europe Disrtribition
Synonyms: Mitochondrial Fission 1 Protein; FIS1 Homolog; hFis1; Tetratricopeptide Repeat Protein 11; TPR Repeat Protein 11; FIS1; TTC11; CGI-135
Active Protein: N/A
Activity: Recombinant Human Mitochondrial Fission 1 Protein is produced by our E.coli expression system and the target gene encoding Met1-Gly122 is expressed with a 6His tag at the C-terminus.
Protein Construction: Recombinant Human Mitochondrial Fission 1 Protein is produced by our E.coli expression system and the target gene encoding Met1-Gly122 is expressed with a 6His tag at the C-terminus.
Fusion Tag: C-6His
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 15.2 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM Tris, pH 8.0.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Mitochondrial Fission 1 Protein (FIS1) is a member of the FIS1 family. FIS1 is a single-pass membrane protein and contains one TPR repeat. FIS1 is part of the mitochondrial complex that promotes mitochondrial fission. FIS1 can induce cytochrome C discharge from the mitochondrion to the cytosol, eventually leading to apoptosis. In addition, FIS1 participates in peroxisomal growth and division. The C-terminus of FIS1 is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L.
Research Area: Cell biology, Cancer, metabolism
