Recombinant Human MINPP1 Protein (His Tag) | PKSH032767

Recombinant Human MINPP1 Protein (His Tag) | PKSH032767 | Gentaur US, UK & Europe Disrtribition

Synonyms: Multiple Inositol Polyphosphate Phosphatase 1; 2, 3-Bisphosphoglycerate 3-Phosphatase; 2, 3-BPG Phosphatase; Inositol (1, 3, 4, 5)-Tetrakisphosphate 3-Phosphatase; Ins(1, 3, 4, 5)P(4) 3-Phosphatase; MINPP1; MIPP

Active Protein: N/A

Activity: Recombinant Human Multiple Inositol Polyphosphate Phosphatase 1 is produced by our Mammalian expression system and the target gene encoding Ser31-Leu487 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Multiple Inositol Polyphosphate Phosphatase 1 is produced by our Mammalian expression system and the target gene encoding Ser31-Leu487 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 53.1 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 10% Glycerol, pH 7.5.

Reconstitution: Not Applicable

Background: Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 is an enzyme that removes 3-phosphate from inositol phosphate substrates. MINPP1 also converts 2, 3 bisphosphoglycerate (2, 3-BPG) to 2-phosphoglycerate. MINPP1 is synthesized as a 487 amino acid precursor that contains an 30 amino acid signal peptide and a 457 amino aicd mature chain. MINPP1 is widely expressed with the highest levels found in kidney, liver and placenta. It acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). MINPP1 may play a role in bone development (endochondral ossification).

Research Area: Signal Transduction,