Description
Recombinant Human METAP1 Protein | PKSH033589 | Gentaur US, UK & Europe Disrtribition
Synonyms: Methionine aminopeptidase 1; MAP 1; MetAP 1; Peptidase M 1; METAP1;MAP1A;MetAP1A
Active Protein: N/A
Activity: Recombinant Human METAP1 is produced by our E.coli expression system and the target gene encoding Met1-Phe386 is expressed.
Protein Construction: Recombinant Human METAP1 is produced by our E.coli expression system and the target gene encoding Met1-Phe386 is expressed.
Fusion Tag: N/A
Species: Human
Expressed Host: E.coli
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Molecular Mass: 43.2 kDa
Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, 10%glycerol, pH8.0.
Reconstitution: Not Applicable
Background: Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.
Research Area: Signal Transduction, metabolism,
