Description
Recombinant Human Mesothelin/MSLN Protein (aa 296-580, Fc Tag) | PKSH030720 | Gentaur US, UK & Europe Disrtribition
Synonyms: Megakaryocyte potentiating factor; mesothelin; Pre-pro-megakaryocyte-potentiating factor; soluble MPF mesothelin related protein;CAK1; MPF; MSLN; SMR; CAK1; CAK1 antigen
Active Protein: N/A
Activity: A DNA sequence encoding the human MSLN (Q13421-2) (Glu296-Gly580) was expressed;with the fused Fc region of human IgG1 at the N-terminus.
Protein Construction: A DNA sequence encoding the human MSLN (Q13421-2) (Glu296-Gly580) was expressed;with the fused Fc region of human IgG1 at the N-terminus.
Fusion Tag: N-Fc
Species: Human
Expressed Host: HEK293 Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 60.7 kDa
Formulation: Lyophilized from sterile PBS, pH 7.4
Reconstitution: Please refer to the printed manual for detailed information.
Background: Megakaryocyte potentiating factor belongs to the mesothelin family. This family is comprised by several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells; mesotheliomas; and ovarian cancer; but the biological function of the protein is not known. Megakaryocyte potentiating factor is highly expressed in mesotheliomas; ovarian cancers; and some squamous cell carcinomas (at protein level). It interacts with MUC16 and potentiates megakaryocyte colony formation in vitro. Megakaryocyte potentiating factor is secreted by several mesothelioma cell lines and is frequently elevated in the blood of patients with mesothelioma. Measurement of this protein may be useful in following the response of mesothelioma to treatment.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Research Area: N/A
