Recombinant Human Merlin/NF2 protein (His Tag) | PKSH500004

Recombinant Human Merlin/NF2 protein (His Tag) | PKSH500004 | Gentaur US, UK & Europe Disrtribition

Synonyms: CAN, BANF, Bilateral acoustic neuroma, MERL_HUMAN, Merlin, Moesin ezrin radixin like protein, Moesin ezrin radizin like, Moesin-ezrin-radixin-like, Neurofibromatosis 2, Neurofibromatosis type 2, Neurofibromatosis2, NF 2, SCH, Schwannomerlin

Active Protein: Active protein

Activity: A DNA sequence encoding the Human Merlin/NF2 (P35240-1) (1M-595L) was expressed with a polyhistidine tag at the N-terminus.

Protein Construction: A DNA sequence encoding the Human Merlin/NF2 (P35240-1) (1M-595L) was expressed with a polyhistidine tag at the N-terminus.

Fusion Tag: N-His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 69.7kDa

Formulation: Supplied as sterile Tris, EDTA, PH 8.0.

Reconstitution: Not Applicable

Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Research Area: N/A