Recombinant Human MAN1B1 Protein (His Tag) | PKSH032400

Recombinant Human MAN1B1 Protein (His Tag) | PKSH032400 | Gentaur US, UK & Europe Disrtribition

Synonyms: Endoplasmic Reticulum Mannosyl-Oligosaccharide 1;2-Alpha-Mannosidase; ER Alpha-1;2-Mannosidase; ER Mannosidase 1; ERMan1; Man9GlcNAc2-Specific-Processing Alpha-Mannosidase; Mannosidase Alpha Class 1B Member 1; MAN1B1

Active Protein: N/A

Activity: Recombinant Human Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase/MAN1B1 is produced by our Mammalian expression system and the target gene encoding Asp106-Ala699 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase/MAN1B1 is produced by our Mammalian expression system and the target gene encoding Asp106-Ala699 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 68.7 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 50mM TrisHCL, 10mM reduced Glutathione, pH 8.0.

Reconstitution: Not Applicable

Background: Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.

Research Area: Tags & Cell Markers