Description
Recombinant Human LRRC32/GARP (C-Fc) | PKSH033979 | Gentaur US, UK & Europe Disrtribition
Synonyms: GARP; GARPGarpin; Garpin; D11S833E
Active Protein: N/A
Activity: Recombinant Human Transforming Growth Factor Beta Activator LRRC32 is produced by our Mammalian expression system and the target gene encoding His20-Asn627 is expressed with a Fc tag at the C-terminus.
Protein Construction: Recombinant Human Transforming Growth Factor Beta Activator LRRC32 is produced by our Mammalian expression system and the target gene encoding His20-Asn627 is expressed with a Fc tag at the C-terminus.
Fusion Tag: C-Fc
Species: Human
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 92.9 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Leucine Rich Repeat Containing 32 (LRRC32), also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated T(regs). LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation. LRRC32 is widely expressed during embryogenesis and on adult platelets. Human LRRC32 is identified as a lineage specific key receptor for human T cells.
Research Area: N/A
