Recombinant Human LMCD1/Dyxin Protein (His Tag) | PKSH032706

Recombinant Human LMCD1/Dyxin Protein (His Tag) | PKSH032706 | Gentaur US, UK & Europe Disrtribition

Synonyms: LIM and cysteine-rich domains protein 1; LMCD1; Dyxin

Active Protein: N/A

Activity: Recombinant Human LIM and cysteine-rich domains protein 1 is produced by our E.coli expression system and the target gene encoding Met1-Ser365 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.

Protein Construction: Recombinant Human LIM and cysteine-rich domains protein 1 is produced by our E.coli expression system and the target gene encoding Met1-Ser365 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.

Fusion Tag: N, C-6His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 44.0 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB，150mM NaCl, pH7.4.

Reconstitution: Not Applicable

Background: LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

Research Area: Signal Transduction, Neuroscience,