Description
Recombinant Human Leukocyte Ig-Like Receptor B2/LILRB2/ILT4/CD85d (C-Avi-6His) Biotinylated | PKSH033919 | Gentaur US, UK & Europe Disrtribition
Synonyms: Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2; LIR-2; Leukocyte Immunoglobulin-Like Receptor 2; CD85 Antigen-Like Family Member D; Immunoglobulin-Like Transcript 4; ILT-4; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; MIR-10; CD85d; LILRB2; ILT4; LIR2; MIR10
Active Protein: N/A
Activity: Recombinant Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 is produced by our Mammalian expression system and the target gene encoding Gln22-His458 is expressed with a Avi, 6His tag at the C-terminus.
Protein Construction: Recombinant Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 is produced by our Mammalian expression system and the target gene encoding Gln22-His458 is expressed with a Avi, 6His tag at the C-terminus.
Fusion Tag: C-Avi-6His
Species: Human
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 50.2 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
Research Area: N/A
