Recombinant Human Latexin/LXN Protein (His Tag) | PKSH031755

Recombinant Human Latexin/LXN Protein (His Tag) | PKSH031755 | Gentaur US, UK & Europe Disrtribition

Synonyms: ECI;TCI

Active Protein: N/A

Activity: A DNA sequence encoding the human Latexin (NP_064554.3) (Glu 2-Glu222) was expressed; fused with a polyhistidine tag at the N-terminus.

Protein Construction: A DNA sequence encoding the human Latexin (NP_064554.3) (Glu 2-Glu222) was expressed; fused with a polyhistidine tag at the N-terminus.

Fusion Tag: N-His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 97 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 26.8 kDa

Formulation: Lyophilized from sterile 20mM HEPES, 0.1M KCl, pH 7.5

Reconstitution: Please refer to the printed manual for detailed information.

Background: Latexin; also known as endogenous carboxypeptidase inhibitor; tissue carboxypeptidase inhibitor; TCI; ECI and LXN; is a cytoplasm protein which belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in heart; prostate; ovary; kidney; pancreas; and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart; prostate; ovary; kidney; pancreas; and colon; but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets; and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors; Latexin is related to a human putative tumor suppressor protein; TIG1. In addition; Latexin is also implicated in Alzheimer's disease.

Research Area: Tags & Cell Markers, Cell biology, Neuroscience, immunology, Stem cells