Description
Recombinant Human KIR2DL3 Protein (His Tag) | PKSH033319 | Gentaur US, UK & Europe Disrtribition
Synonyms: Killer Cell Immunoglobulin-Like Receptor 2DL3; CD158 Antigen-Like Family Member B2; KIR-023GB; Killer Inhibitory Receptor cl 2-3; MHC Class I NK Cell Receptor; NKAT2a; NKAT2b; Natural Killer-Associated Transcript 2; NKAT-2; p58 Natural Killer Cell Receptor Clone CL-6; p58 NK Receptor CL-6; p58.2 MHC Class-I-Specific NK Receptor; CD158b2; KIR2DL3; CD158B2; KIRCL23; NKAT2;KIR-K7b;KIR-K7c;KIR2DS5;KIRCL23;MGC129943;NKAT;NKAT2;NKAT2A;NKAT2B
Active Protein: N/A
Activity: Recombinant Human killer cell immunoglobulin-like receptor 2DL3 is produced by our Mammalian expression system and the target gene encoding His22-His245 is expressed with a 6His tag at the C-terminus.
Protein Construction: Recombinant Human killer cell immunoglobulin-like receptor 2DL3 is produced by our Mammalian expression system and the target gene encoding His22-His245 is expressed with a 6His tag at the C-terminus.
Fusion Tag: C-6His
Species: Human
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 25.4 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.
Research Area: N/A
