Recombinant Human Interleukin-35/IL-35 (C-Fc) | PKSH033974

Recombinant Human Interleukin-35/IL-35 (C-Fc) | PKSH033974 | Gentaur US, UK & Europe Disrtribition

Synonyms: Interleukin 35; IL35; hIL35

Active Protein: N/A

Activity: Recombinant Human Interleukin-35 is produced by our Mammalian expression system and the target gene encoding Arg23-Ser219&Arg21-Lys229 is expressed with a Fc tag at the C-terminus.

Protein Construction: Recombinant Human Interleukin-35 is produced by our Mammalian expression system and the target gene encoding Arg23-Ser219&Arg21-Lys229 is expressed with a Fc tag at the C-terminus.

Fusion Tag: C-Fc

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: >90% as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 73.7 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Interleukin-35 is a newest and potent suppressive cytokine of the IL-12 family. Unlike other members of the IL-12 family which are produced mainly by antigen-presenting cells (APCs), IL-35 has been identified as a potentially immunosuppressive cytokine primarily produced by regulatory T (Treg) cells, and to a lesser extent by activated dendritic cells and macrophages. IL-35 is composed of the IL-12 p35 subunit and the IL-27 Epstein–Barr virus-induced protein 3 (EBI3) subunit. IL-35 plays an important role in many disease models and has been recently shown to have additional functions aside from inhibition of proliferation, including inducing its own expression in non-Treg cells.

Research Area: Cancer, immunology